NITRALZ® One Source – INNOVATIVE SOLUTIONS
Our NITRALZ® products are used as intermediates for the API (active pharmaceutical ingredient) production.
AlzChem is the independent and reliable Western source for many nitriles / gas phase reactions.
By special distillation we achieve high quality and purity of our nitriles. Furthermore we are proud of our in-house catalyst development. By applying our extensive catalyst Know-How and innovation thoughts we have branched out into additional groups of molecules, like ketones (e.g. 3-Acetylpyridine).
To meet your needs our R&D works closely with your team to develop advanced chemical solutions.
Thus the production from gram scale to ton scale is no problem for us.
High quality nitriles via gas phase technology MADE IN GERMANY:
We offer a broad product portfolio for the production of APIs.
AlzChem features e.g. 2-Chlorobenzonitrile (CAS No. 1867-66-9) available from stock in three different qualities:
- Standard Quality – as organic building block for industrial use.
- Extra Pure Quality – mainly used for the production of Ketamine hydrochloride.
- Super Quality – with the highest purity of min. 99,5%, an outstanding quality is available for active pharmaceutical ingredients.
Furthermore our NITRALZ® 4-Aminobenzonitrile serves as essential intermediate for APIs like Dabigatran or Frovatriptan.
Another product we would like to highlight is our 3-Acetylpyridine, which is used for the production of the API Imatinib.
Please find here a few examples of our nitriles mainly used as intermediates for pharmaceuticals for human and veterinary use:
Human medicine application:
|
NITRALZ®
|
CAS No.
|
application area examples
|
end product examples
|
|---|
|
4-Aminobenzonitrile
|
873-74-5
|
anti-migrane
anti-atherosclerotic
anticoagulant
treatment of HIV
anti-cancer
anti-asthmatic
|
Dabigatran
Frovatriptan
Goxalapladib
Rilpivirine
|
|
2-Bromobenzonitrile
|
2042-37-7
|
anti-hypertensive
anti-epileptic
|
Irbesartan
Perampanel
|
|
4-Bromobenzonitrile
|
623-00-7
|
analgesic
ocular anti-inflammatory
|
Bromfenac
|
|
2-Chlorobenzonitrile
|
873-32-5
|
anti-hypertensive
analgesic
hypnotic
anesthetic
|
Ketamine Hydrochloride
|
|
4-Chlorobenzonitrile
|
623-03-0
|
anti-allergic
aromatase inhibitor
|
Lodoxamide Tromethamine
|
|
2,3-Dichlorobenzonitrile
|
6574-97-6 |
anti-epileptic |
Lamotrigine |
|
2,4-Dichlorobenzonitrile
|
6574-98-7
|
treatment of HIV
|
Dolutegravir
|
|
Pivalonitrile
|
630-18-2
|
bronchodilator
|
Pirbuterol
|
|
4-Tolunitrile
|
104-85-8
|
anti-histaminic
hemostatic
anti-ulcerative
anti-neoplastic
|
Letrozole
|
| 3-Acetylpyridine |
350-03-8 |
anti-leukemia drug |
Imatinib |
Veterinary medicine application:
|
NITRALZ®
|
CAS No.
|
application area examples
|
end product examples
|
|---|
|
Benzonitrile
|
100-47-0
|
antibacterial
|
Florfenicol, Robenacoxib
|
|
n-Butyronitrile
|
109-74-0
|
anticoccidial
|
Amprolium
|
|
4-Chlorobenzonitrile
|
623-03-0
|
contraceptive
|
Lotrifen
|
|
3-Acetylpyridine
|
350-03-8
|
tyrosine-kinase inhibitor treatment of mast cell tumors
|
Masitinib
|
Special solvents:
|
NITRALZ®
|
CAS No.
|
|---|
|
n-Butyronitrile
|
109-74-0
|
|
Pivalonitrile
|
630-18-2
|
|
4-Heptanone
|
123-19-3
|
Did you know that …
Over 30 nitrile-containing pharmaceuticals are prescribed for a diverse variety of medicinal indications with more than 20 additional nitrile-containing leads in clinical development.
The nitrile group is quite robust and, in most cases, is not readily metabolized but passes through the body unchanged. The types of pharmaceuticals containing nitriles are diverse, from vildagliptin, an antidiabetic drug, to anastrozole, which is the gold standard in treating breast cancer. In many instances the nitrile mimics functionality present in substrates for enzymes, whereas in other cases the nitrile increases water solubility or decreases susceptibility to oxidative metabolism in the liver. The nitrile functional group is found in several drugs. (Fleming et al. 2010: 7902)
Fleming, Fraser F.; Lao, Lihua; Ravikumar, P.C; Funk, Lee and Shook, Brian C. (2010): Nitrile-Containing Pharmaceuticals. Efficacious Roles of the Nitrile Pharmacophor, in: Journal of Medicinal Chemistry. 53 (22), pp 7902-7917.
