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Medicines with NITRALZ®

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From A for anastrozole to V for vildagliptin: drug types containing nitriles are diverse and are not only suitable for the treatment of breast cancer or diabetes. Currently, more than 30 nitrile-containing drugs are known for a variety of medical indications. Another 20 active substances containing nitrile are still in clinical development (cf. Fleming et al. 2010: 7902).*

Highest quality & purity

Nitrile as intermediate products for the production of APIs.

Our NITRALZ® products are used as intermediates for API (active pharmaceutical ingredients) production. Via special distillation we achieve high quality and purity as an independent reliable western source. Furthermore we are proud of our in-house catalyst development. By applying our extensive catalyst Know-How and innovation thoughts we have branched out into additional groups of molecules, like ketones e.g. 3-Acetylpyridin.

To meet your needs our R&D works closely with your team to develop advanced chemical solutions.Thus the production from gram scale to ton scale is no problem for us.

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Application expamles

NITRALZ® in human medicine

NITRALZ® CAS Nr. Application area examples End production examples

4-Aminobenzonitrile

873-74-5

anti-migrane

anti-atherosclerotic

anticoagulant

treatment of HIV

anti-cancer

anti-asthmatic

Dabigatran

Frovatriptan

Goxalapladib

Rilpivirin

2-Brombenzonitrile

2042-37-7

anti-hypertensive

anti-epileptic

Irbesartan

Perampanel

4-Brombenzonitrile

623-00-7

analgesic

ocular anti-inflammatory

Bromfenac

2-Chlorbenzonitrile

873-32-5

anti-hypertensive

analgesic

hypnotic

anesthetic

Sartanes

 

Ketamine Hydrochloride

4-Chlorbenzonitrile

623-03-0

anti-allergic

aromatase inhibitor

Lodoxamid
Tromethamine

2,3-Dichlorbenzonitrile

6574-97-6 anti-epileptic Lamotrigine

2,4-Dichlorbenzonitrile

6574-98-7

bronchodilator

Dolutegravir

Pivalonitrile

630-18-2

bronchodilator

Pirbuterol

4-Tolunitrile

104-85-8

anti-histaminic

hemostatic

anti-ulcerative

anti-neoplastic

Letrozole

3-Acetylpyridine 350-03-8 anti-leukemia drug Imatinib
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NITRALZ® Product highlights in human medicine.

Discover two significant NITRALZ® products from our portfolio.

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NITRALZ® von Alzchem

4-Aminobenzonitril

Unser NITRALZ® 4-Aminobenzonitril gilt als essentielles Zwischenprodukt für APIs wie z. B. Dabigatran oder Frovatriptan. Diese beiden Arzneimittel werden in der Behandlung von Migräne und Arteriosklerose eingesetzt.

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NITRALZ® von Alzchem

3-Acetylpyridin

Ein anderes Produkt, das wir hervorheben möchten, ist unser 3-Acetylpyridin, welches für die Herstellung des API Imatinib verwendet wird. Der Wirkstoff wird in der Behandlung von Leukämie eingesetzt.

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Product diversity

Various qualities in stock.

We offer our 2-chlorobenzonitrile, for example, in three different stock qualities:

  • Standard quality: as an organic building block for industrial use.
  • Extra pure quality: mainly used for the production of Ketamine hydrochloride (CAS No. 1867-66-9).
  • Super quality: with the highest purity of min. 99,5%, an outstanding quality is available for active pharmaceutical ingredients.
Application examples

NITRALZ® in veterinary medicine

NITRALZ® CAS Nr. Application area examples end product examples

Benzonitrile

100-47-0

antibacterial

Florfenicol, Robenacoxib

n-Butyronitrile

109-74-0

anticoccidial

Amprolium

4-Chlorbenzonitrile

623-03-0

contraceptive

Lotrifen

3-Acetylpyridine

350-03-8

tyrosine-kinase inhibitor treatment of mast cell tumors

Masitinib

Special solvents in the pharmaceutical sector

NITRALZ® CAS Nr.

n-Butyronitrile

109-74-0

Pivalonitrile

630-18-2

4-Heptanone

123-19-3

Background

How do nitriles act in the body?

The nitrile group is quite robust and, in most cases, is not readily metabolized but passes through the body unchanged. In many instances the nitrile mimics functionality present in substrates for enzymes, whereas in other cases the nitrile increases water solubility or decreases susceptibility to oxidative metabolism in the liver. The nitrile functional group is found in several drugs (Fleming et al. 2010: 7902)*

Here are some examples of our nitriles, which are mainly used as intermediates for pharmaceutical production (human and veterinary applications).

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* Source: Fleming, Fraser F.; Lao, Lihua; Ravikumar, P.C; Funk, Lee and Shook, Brian C. (2010): Nitrile-Containing Pharmaceuticals. Efficacious Roles of the Nitrile Pharmacophor. In: Journal of Medicinal Chemistry.

Discover our product portfolio.

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